Quick facts
Generic name: vardenafil · Class: PDE5 inhibitor · FDA approved: 2003 · Onset: ~30–60 min · Duration: ~4–6 hours · Status: prescription only
Background
Vardenafil received FDA approval in 2003, becoming the second oral ED medication after sildenafil. It is chemically similar to sildenafil and shares a comparable onset and duration, giving men and physicians another well-studied option.
How vardenafil works
Vardenafil inhibits the PDE5 enzyme to preserve cyclic GMP, relaxing penile smooth muscle and improving blood flow during sexual stimulation. In laboratory measures it is a highly potent PDE5 inhibitor, which is why effective doses are numerically lower than sildenafil — though potency in the test tube does not necessarily translate into greater real-world efficacy compared with the other agents.
Onset, duration & how to take it
Vardenafil is generally taken about 30 to 60 minutes before sexual activity, with effects lasting roughly 4 to 6 hours. As with sildenafil, a high-fat meal can slow its absorption, so it is often taken on a relatively empty stomach. It is used as needed and not more than once per day.
What clinical research shows
Vardenafil has been evaluated in numerous randomized, placebo-controlled trials, including studies in men who are often harder to treat — such as those with diabetes or who have had prostate surgery. Across these studies vardenafil significantly improved erectile function compared with placebo. Head-to-head and network comparisons of the PDE5 inhibitors generally find the agents broadly similar in efficacy, with the choice often coming down to tolerability, timing and individual response.
Common side effects
- Headache
- Facial flushing
- Nasal congestion
- Indigestion
- Dizziness
Vardenafil can affect the heart's QT interval, so it may be avoided in people with certain heart-rhythm conditions or who take specific medications — another reason a physician's review is essential.
Important safety information
- Never combine with nitrates or "poppers" — the combination can cause a dangerous drop in blood pressure.
- Tell your doctor about heart-rhythm issues and all medications you take, including alpha-blockers and certain antibiotics or antifungals.
- Be cautious with significant heart disease; get evaluated first.
- Obtain it only by prescription from a licensed pharmacy and avoid counterfeit products sold online.
Frequently asked questions
How long does Levitra take to work?
Usually 30 to 60 minutes. A high-fat meal can delay onset, so it's often taken on a relatively empty stomach.
How is Levitra different from Viagra?
Both are short-acting PDE5 inhibitors with similar onset and duration. Vardenafil is a very potent enzyme inhibitor, but individual tolerability and response vary between the two.
How long does the effect last?
Generally about 4 to 6 hours. Sexual stimulation is still required for it to work.
Is generic vardenafil available?
Yes. Generic vardenafil contains the same active ingredient and meets FDA standards. Your physician or pharmacist can advise on options and cost.
Related reading: Generic Levitra (vardenafil): is it safe & how to check quality · Viagra vs Cialis vs Levitra · Compare all ED medications